Calipso Biosciences

The future of drug discovery is human.

Human iPSC-derived organoids to predict efficacy and safety before clinical trials.

The Problem

R&D is broken: 90% of drug candidates fail, pushing the average cost of an approval to ~$2.6B.

90%
of drug candidates fail
$2.56B
average cost per approved drug
10–15
years to develop a new drug

The Cost of Drug Failures

Over half of R&D costs are lost late in development. One Phase III failure can cost $750 million.

Discovery
~4–5 years
Preclinical
~1 year
Phase I/II
~4 years
Phase III
~2.5 years
Phase III ~$750M at risk
50–70% of total development costs come from late-stage failures

Why Drugs Fail

Late-stage failures are dominated by efficacy and safety.

Efficacy · 52%
Safety · 24%
Other · 24%
Combined impact
76%

of failures are due to safety or efficacy.

Efficacy 52%
Safety 24%
Other 24%

Calipso Bio’s Human-First Solution

A complete pipeline that delivers predictive drug insights through human genetic diversity.

Human Donors
Stage 1
Human Donors

Genetically diverse human donors representing global populations.

iPSCs
Stage 2
iPSCs

Reprogrammed stem cells annotated with detailed pharmacogenetic profiles.

Organoids
Stage 3
Organoids

Functional human tissues modeling real safety and efficacy responses.

Predictive Readouts
Stage 4
Predictive Readouts

Human-relevant data that reveal safety and efficacy before clinical trials.

Coverage Tiers

Number of iPSC lines per tier, and % coverage of CPIC/FDA PGx liabilities.

Tier 1
Essential
30%
PGx iPSC lines4
Control iPSC lines2
Risk coverage:
Catastrophic toxicity Metabolic failures
Tier 2
Core Actionable
60%
PGx iPSC lines12
Control iPSC lines4
Risk coverage:
Metabolic extremes Immune risk Transporters
Tier 3
Comprehensive
90%
PGx iPSC lines32
Control iPSC lines8
Risk coverage:
Dose modifiers Ancestry-specific risks HLA spectrum
Tier 4
Definitive
100%
PGx iPSC lines84
Control iPSC lines12
Risk coverage:
Full FDA/CPIC coverage Redundancy Specialty safety

The future of drug discovery is human

Partner with us to redefine preclinical testing with predictive human biology.

info@calipsobio.com • Vancouver, BC • Typically replies < 24h